Analgesia, maternal and fetal/neonatal side effects and obstetric outcome were double-blind comparison of % bupivacaine/% fentanyl versus. Analgesia, maternal and fetal/neonatal side effects and obstetric outcome were bupivacaine % plus sufentanil µg·mL−1: a study. Presented in part at the Society for Obstetric Anesthesia and boluses of bupivacaine % + fentanyl 2 −1 as part of a programmed.

Author: Goltizragore Kejar
Country: Japan
Language: English (Spanish)
Genre: Marketing
Published (Last): 8 October 2008
Pages: 280
PDF File Size: 5.7 Mb
ePub File Size: 4.14 Mb
ISBN: 691-7-55423-126-5
Downloads: 49412
Price: Free* [*Free Regsitration Required]
Uploader: Zolomi

Levobupivacaine is a single enantiomer LA and a stereoisomer of bupivacaine. Advances in labour analgesia. As a result of this, considerable research has been performed and findings have led to changes in practice.

After childbirth there is no difference in the incidence of long-term back pain, disability or movement restriction between women who have epidurals and those who have not.

The onset of analgesia was significantly faster in 0. Other drugs that have been investigated include epinephrine, ketamine, neostigmine, remifentanil and midazolam. In theory, LDI should decrease anaesthetic workload, provide more constant analgesia and kbstetric haemodynamic stability and sterility. Epidural opioids have a LA dose-sparing effect in labour analgesia.

Hence, various adjutants like adrenaline, clonidine and particularly opioids have been used to reduce the amount of local anaesthetics used and yet provide satisfactory analgesia. Chloroprocaine and lidocaine are also used in the obstetric setting; they are not suitable obwtetric analgesia.

Epidural analgesia in labour | BJA Education | Oxford Academic

The effect of a rapid change in availability of epidural analgesia on the Cesarean delivery rate: Extradural pain relief in labour: Combined spinal epidural versus epidural analgesia in labour.

Low dose top-ups are inherently safe; however a midwife should still be present. There is an association between epidural analgesia and labour outcome, but this is probably not causative. It has been promoted as having less motor blocking effect as well as a better safety profile than bupivacaine. Sign In or Create an Account.


This may merely reflect the fact that women with complicated, painful labours might request epidural analgesia more often. Only preservative-free morphine should be used intrathecally. The mode of delivery and the Apgar scores of the neonates at 1 and 5 minutes were comparable. The following statement from the American College of Obstetricians and Gynecologists summarizes the background to these figures: Though randomized controlled trials RCT are considered the gold standard for research, in labour they can be difficult to blind and therefore, there is potential for observer bias.

With low dose top-ups, there is a reduction in total LA dose when compared with epidural infusions.

ogstetric In addition, there are equipment and cost issues to consider. Continuous infusion epidural analgesia in obstetrics: Nulliparity and labour longer than 12 h were also independent predictors for maternal pyrexia. In the UK, a popular combination for epidural infusions or bolus top-ups is a solution of bupivacaine 0. These also refer to intermittent boluses by the midwife or anaesthetist but with low dose LA, usually with fentanyl.

Effect of pH-adjustment of bupivacaine on onset and duration of epidural analgesia in parturient. Unrelieved labour pain produces many physiological changes which are detrimental to both the mother and the foetus.

This article was originally published in. Whatever the influence of epidural analgesia on labour, it is obvious that obstetric management will have an impact on the mode of delivery. The risk of postpartum back pain is not increased. Effect of epidural analgesia on labour and outcome.

Uterine activity appears to be unaffected by induction of regional block. Continuous epidural infusion of 0. Sufentanil is used extensively in the US. Several recent, well-powered RCTs confirm that epidural analgesia during labour is not associated with an increased incidence of back pain after childbirth.

Lidocaine is not popular for labour analgesia as repeated doses cause tachyphylaxis. Epidural analgesia during labour-comparison of 0.


Disadvantages of CSE often cited are that they are more invasive and costly. Randomised obsstetric comparison of epidural bupivacaine versus pethidine for analgesia in labour. The meta-analysis did show more frequent use of oxytocin to augment labour in the epidural group.

There was a problem providing the content you requested

No consistent differences have been identified in neonatal arterial pH or APGAR scores in babies who are born to mothers with epidurals. Opioids can be added to LA or used as a sole epidural or intrathecal agent to provide analgesia for labour Table 1. However, it is not always associated with improved maternal satisfaction.

CJA ; 38 3: No clear advantages have been demonstrated when compared with midwife administered low dose top-ups. It undergoes ester hydrolysis; minimizing placental transmission but its duration of action is too short for analgesia.

Compared with other methods, epidural analgesia provides superior analgesia in labour. This would suggest that ropivacaine does not have a superior sensory-motor split when compared with bupivacaine.

Since epidural analgesia was introduced four decades ago for pain relief in labour, controversy has persisted about its effect on the labour process. In MLAC studies, the relative analgesic potency of ropivacaine to bupivacaine was 0. Bearing in mind the above, how can we optimize labour epidural analgesia to ensure superior analgesia while minimizing the effects on labour? Although there have been case reports of meningitis associated with CSE, a systematic review of CSE vs epidural analgesia did not suggest an increased incidence.