extract of Glycyrrhiza glabra Linn. in aspirin induced ulcer in rats. . The aim of the study was to determine anti ulcer activity of stem bark of. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total Keywords: Anti-ulcer, Cold-restraint, Glycyrrhiza glabra, GutGardTM. The present research has been carried out to investigate antiulcer activity of ethanolic extract of Cynodon dactylon, Ocimum sanctum, Glycyrrhiza glabra, Ficus.

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Effects antiulce the new anti-ulcer agent KB on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine. Please review our privacy policy. Number of advantages are associated with use of herbal medicines as opposed to pharmaceutical products some of which include include reduced risk of side effects, effectives with chronic conditions, lower cost, widespread availability.

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Anti-ulcer activity of aqueous and ethanolic extracts of Glycyrrhiza glabra L. in rats.

He has completed B. The general signs of toxicity i. Prophylactic and curative effects of Bacopa monniera in gastric ulcer models.

The extract was stored in refrigerator and reconstituted in water for injection. There were no significant changes in food and water intake and or body weight during the 14 days of observation data not shown. Gastric mucosal antiulcsr changes induced by indomethacin male albino rats. Effects of naringenin and quercetin on experimental chronic gastric ulcer in rat studies on the histological findings.

Principally glycyrrhizin reduces ROS generation which is the potent mediator of tissue inflammation. The genus glycyrrhiza consists of approximately 30 species, in which antiulccer species produce a sweet saponin glycyrrhizic acid GAthat is widely used in the confectionery and pharmaceutical industries in various countries 1. Ann Jose ankara escort.

The plant kingdom as a source of antiulcer remedies. Og doses of hydroalcoholic extract of G. Its pathogenesis is influenced by acid-pepsin secretion, cellular regeneration, mucus secretion, blood flow, mucosal barrier, prostaglandins, epidermal growth 5 and Helicobacter pylori infection 6.


Omeprazole was most effective; it reduced the ulcer index to Modern trends in toxicology. Gastric and duodenal peptic ulcers affect thousands of people and in the clinical practice are the most common gastrointestinal disorders. This model, cold restraint stress-induced gastric glbra, has been used due to data reproducibility and similarity with human gastric ulcers to evaluate the effect of drugs on gastric secretion, stress and gastrointestinal motility.

Stress increases the formation of ROS, decreases the cell proliferation rate, increases gastric juice secretion, and promotes inhibition of prostaglandin synthesis, leading to alterations in the circulating nitric oxide and the gastric mucosa However, studies are needed to glabrs the safety of its use, as well as the analysis of acute toxicity is fundamentally important to identify the doses that could be used, and to reveal the possible clinical signs caused by the extract.

One hour after the treatments, all animals received 0. The animals were kept under 12 h light-dark cycle and received water and commercial food ad libitum. The aim of present study was to determine the anti ulcer activity of polyherbal formulation including Aloe vera and Glycyrrhiza glabra against aspirin and ethanol induced gastric ulceration in Swiss albino rats. Memory enhancing activity of Glycyrrhiza glabra in mice.

All the treatments were administered as oral aqueous suspension and the animals of the control group received saline as vehicle. Find articles by Vahid Najarnezhad.

Thirty minutes after the administration glycyfrhiza ethanol, the mice were killed by cervical dislocation, and the stomach was removed and opened along the greater curvature.

According to the method of Cerqueira et al. Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats.

Medicinal plants are among the most attractive source of new drugs with hopeful results in peptic ulcer management Many drugs are in the market to treat glycjrrhiza, but they have lot of adverse effects.

Several studies have indicated that Glycyrrhiza glabra extract or its derivatives, mainly glycyrrhizin, bear expectorant, diuretic, laxative, sedative, antipyretic, antimicrobial and anxiolytic, antiviral, anti-inflammatory and antioxidant activities 4. Can’t read the image?


Besides, being a popular food additive, licorice is also one of the most widely used medicinal herbs in Iran. Open in a separate window. The stomachs were gently rinsed with water to remove the gastric contents and blood clots, for subsequent examination. Peptic ulcer glaabra caused 0. The hydroalcoholic extract of G. Endogenous prostaglandins regulate mucosal blood flow, epithelial cell proliferation, epithelial restitution, mucosal immunocyte function, mucus and bicarbonate secretion, and basal acid secretion.

Iran J Pharm Res. Gastroduodenal ulcer protective activity of Asparagus racemosus: However they are very expensive and have multiple side effects that limit their acfivity.

Anti Ulcer Activity Of Aloevera And Glycyrrhiza Glabra In Swiss Albino Rats |

Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic agents in rats. It seems that by raising the local concentration of prostaglandins that promote mucous secretion and cell proliferation in the stomach, leading to healing of ulcers in experimental studies All chemicals and extract doses were prepared immediately before use.

Two mechanisms have glyfyrrhiza suggested includeing inhibition of glucocorticoid metabolism and potentiating their effects, and inhibition of classical complement pathway activation. Acknowledgment The authors gljcyrrhiza appreciate the financial support by the faculty of Veterinary Medicine Urmia University, Iran.

The experiment was performed by the method of Sairam et al. The animals were euthanized and the stomachs were removed and opened along the greater curvature. Omeprazole ov significantly inhibited the ethanol-induced gastric lesion It was observed that the hydroalcoholic extract of G. A depletion of stomach wall mucus after oral ethanol administration has also been reported