Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as additive to the UV filter avobenzone in cosmetic sunscreen formulations – Evaluation. DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE. Health Concerns of the Ingredient: Overall Hazard. Cancer. Developmental & reproductive toxicity. Opinion on diethylamino hydroxybenzoyl hexyl benzoate. 2. About the Scientific Committees. Three independent non-food Scientific.

Author: Gokasa Doukazahn
Country: Morocco
Language: English (Spanish)
Genre: Life
Published (Last): 2 January 2004
Pages: 360
PDF File Size: 18.36 Mb
ePub File Size: 8.41 Mb
ISBN: 452-5-52503-654-4
Downloads: 17477
Price: Free* [*Free Regsitration Required]
Uploader: Gukasa

This effect is more pronounced at higher water temperatures.

Encouraging the manufacture of reef-friendly sunscreens. Diethylamino hydroxybenzoyl hexyl benzoate 0. Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe inand is also marketed in the U.

They are generally found at barely detectable benzoatr of a few parts per trillion but much higher concentrations of over 1 part per million ppm have been reported in a few locations e.

Drug created on December 03, Most experiments have also been of relatively short duration 12 or 24 hours. The chemical UV filter oxybenzone has been studied most intensively and the following effects have been described: Damage to coral DNA and to their reproductive success.

Diethylamino hydroxybenzoyl hexyl benzoate

Further research is needed to better understand which ingredients are safe and which pose a realistic threat to marine ecosystems, in particular: No case of overdose has been reported.

Diethylamino hydroxybenzoyl hexyl benzoate was not shown to be mutagenic, clastogenic, or phototoxic in vitro [ 4 ].

  ASTRON N2412-12 PDF

Reducing the amount of harmful sunscreen components that reach the reef doethylamino is a high priority and will require the involvement of governments, reef benzowte, divers, snorkelers and swimmers, and the tourism and pharmaceutical industries.

Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at nm [ 1 ]. Based on the findings of a rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum [ 4 ].

Diethylamino hydroxybenzoyl hexyl benzoate – Wikipedia

Hhexyl following measures are recommended:. Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure of UV radiation on human skin [ 2 ]. Considering the many stresses already faced by reefs and current concerns about the toxicity of certain components of sunscreens to corals, a dietyylamino and precautionary approach to dealing with this issue may be required. Diethylamino hydroxybenzoyl hexyl benzoate. To date, experiments have largely been undertaken ex-situ and there are concerns that they may not properly reflect conditions on the reef, where pollutants could be rapidly dispersed and diluted.

In vitrotopical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by inhibiting oedema formation [ 3 ].

Bleaching of coral fragments and coral cells from various species of hard coral. Damage and deformation of coral larvae planulae. Many of these components have also been found in marine biota including fish, molluscs and corals as well as in sediments.


Like other UV filters, diethylamino hydroxybenzoyl hexyl benzoate may be subject to photodegradation upon absorption of UV radiation, which results in the compound passing from a ground state to either a singlet or triplet excited state [ 1 ]. Further research is needed to better understand which ingredients are safe and which pose a realistic threat to marine ecosystems, in particular:.

It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability [ 1 ]. They also contain inactive ingredients such as anti-microbial preservatives, moisturisers and anti-oxidants. Identifying those ingredients that are safe and those that pose a realistic threat to marine ecosystems.

Studying the effects of pharmaceutical and personal care products PPCP mixtures to provide a more realistic picture of ecological risks posed by the use of these products. Investigating UV filter toxicity in relation to predicted hyfroxybenzoyl and ocean acidification conditions.


Induction of the lytic viral cycle in diethylaimno zooxanthellae with latent infections. Impacts of sunscreens on coral reefs. The chemical UV filter oxybenzone has been studied most intensively and the following effects have been described:. In rat and porcine skin, the percutaneous absorption was 0. Where sunscreen components have been detected, concentrations are very variable.